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SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway

4 Feb 2023

Abstract excerpt

SARS-Cov-2 infection, which has caused the COVID-19 global pandemic, triggers cellular senescence. In this study, we investigate the role of the SARS-COV-2 spike protein (S-protein) in regulating the senescence of RPE cells. The results showed that administration or overexpression of S-protein in ARPE-19 decreased cell proliferation with cell cycle arrest at the G1 phase. S-protein increased SA-β-Gal positive...

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PMID: 36738354
DOI: 10.1007/s10522-023-10019-0

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