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Article

A high prevalence of neutrophil-specific antibodies in ELANE-mutated severe congenital neutropenia.

Pediatric blood & cancer - 1 Apr 2023

Dobrewa Weronika, Madzio Joanna, Babol-Pokora Katarzyna, Lopacz Patrycja, Gierszon Agnieszka, Guz Katarzyna, Orzinska Agnieszka, Uhrynowska Malgorzata, Jasinska Aleksandra, Zdunek Maciej, Mlynarski Wojciech, Janczar Szymon

Abstract excerpt

An assay for neutrophil-specific antibodies is frequently used in the workup of chronic severe neutropenia and is suggestive of autoimmune, or sporadically alloimmune neutropenia, rather than severe congenital neutropenia (SCN). We analyzed a neutropenia consortium database for the outcomes of antibody testing initiated before receiving genetic diagnosis in Polish SCN cohort. Test results, performed in a single...

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PMID: 36734404
DOI: 10.1002/pbc.30247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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