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Article

In it for the long run: perspectives on exploiting long-read sequencing in livestock for population scale studies of structural variants.

Genetics, selection, evolution : GSE - 31 Jan 2023

Nguyen Tuan V, Vander Jagt Christy J, Wang Jianghui, Daetwyler Hans D, Xiang Ruidong, Goddard Michael E, Nguyen Loan T, Ross Elizabeth M, Hayes Ben J, Chamberlain Amanda J, MacLeod Iona M

Abstract excerpt

Studies have demonstrated that structural variants (SV) play a substantial role in the evolution of species and have an impact on Mendelian traits in the genome. However, unlike small variants (< 50 bp), it has been challenging to accurately identify and genotype SV at the population scale using short-read sequencing. Long-read sequencing technologies are becoming competitively priced and can address several of...

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PMID: 36721111
DOI: 10.1186/s12711-023-00783-5
PMCID: PMC9887926

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