Article
The genetics of non-monogenic IBD.
Human genetics - 1 May 2023
Jans Deborah, Cleynen Isabelle
Abstract excerpt
Inflammatory bowel disease (IBD), with Crohn's disease and ulcerative colitis as main subtypes, is a prototypical multifactorial disease with both genetic and environmental factors involved. Genetically, IBD covers a wide spectrum from monogenic to polygenic forms. In polygenic disease, many genetic variants each contribute a small amount to disease risk. With the advent of genome-wide association studies (GWAS),...
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