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Article

Folding of Cu, Zn superoxide dismutase and familial amyotrophic lateral sclerosis.

Journal of molecular biology - 28 Nov 2003

Khare Sagar D, Ding Feng, Dokholyan Nikolay V

Abstract excerpt

Cu, Zn superoxide dismutase (SOD1) has been implicated in the familial form of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). It has been suggested that mutant mediated SOD1 misfolding/aggregation is an integral part of the pathology of ALS. We study the folding thermodynamics and kinetics of SOD1 using a hybrid molecular dynamics approach. We reproduce the experimentally observed SOD1 folding...

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Source

Identifiers

PMID: 14623191
DOI: 10.1016/j.jmb.2003.09.069

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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