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Article

The risk of major bleeding in patients with factor V Leiden or prothrombin G20210A gene mutation while on extended anticoagulant treatment for venous thromboembolism.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2023

Caiano Lucia, Kovacs Michael J, Lazo-Langner Alejandro, Anderson David R, Kahn Susan R, Shah Vinay, Kaatz Scott, Zide Russell S, Schulman Sam, Chagnon Isabelle, Mallick Ranjeeta, Rodger Marc A, Wells Philip S

Abstract excerpt

BACKGROUND: Thrombophilia predisposes to venous thromboembolism (VTE) because of acquired or hereditary factors. Among them, it has been suggested that gene mutations of the factor V Leiden (FVL) or prothrombin G20210A mutation (PGM) might reduce the risk of bleeding, but little data exist for patients treated using anticoagulants. OBJECTIVES: To assess whether thrombophilia is protective against bleeding....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36710196
DOI: 10.1016/j.jtha.2022.12.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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