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Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells

27 Jan 2023

Abstract excerpt

Dermal papilla cells (DPCs) play critical roles in hair follicle development, but the underlying mechanisms that contribute to hair regeneration have yet to be fully elucidated, particularly in terms of alterations in androgenetic alopecia patients. In this study, we demonstrated that hypoxia-inducible factor-1α (HIF-1α) is suppressed in scalp tissues of androgenetic alopecia patients and potentially associated...

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PMID: 36707659
DOI: 10.1038/s41598-023-28837-0

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