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Bioinformatics analysis and experimental studies reveal KPNA2 as a novel biomarker of hepatocellular carcinoma progression and telomere maintenance

16 Jul 2025

Abstract excerpt

BACKGROUND: Telomere maintenance mechanisms (TMMs) play a distinct role in the initiation and progression of hepatocellular carcinoma (HCC). However, the prognostic relevance of telomere maintenance (TM)-related genes in HCC remains largely unclear. METHODS: We integrated expression profiles of TM-related genes and corresponding clinicopathological data from public databases. Univariate analyses were performed to...

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PMID: 40665355
DOI: 10.1186/s40001-025-02866-z

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