RIP3 impedes Mycobacterium tuberculosis survival and promotes p62-mediated autophagy

Abstract excerpt

Macrophage is believed to play a vital role in the fight against Mycobacterium tuberculosis (M.tb) infection by activating autophagy. Recently, receptor-interacting protein kinase-3 (RIP3), an essential kinase for necroptotic cell death signaling, has been demonstrated to be involved in autophagy. However, RIP3′s role in fighting against M.tb infection remains elusive. Here we show that a substantial increase in...

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