Article
Patients with Asian-type DEL can safely be transfused with RhD-positive blood.
Blood - 27 Apr 2023
Ji Yanli, Luo Yalin, Wen Jizhi, Sun Yuanfan, Jia Shuangshuang, Ou Chunquan, Yang Wenbing, Chen Jingwang, Ye Hanshen, Liu Xiangfu, Liang Yongneng, Lu Zhigang, Feng Ying, Wu Xinzhong, Xiao Muzhou, Mo Jiankun, Zhou Zhenhai, Wang Zhen, Liao Zhijian, Chen Junhu, Wei Ling, Luo Guangping, Santoso Sentot, Fichou Yann, Flegel Willy Albert, Shao Chaopeng, Li Chengyao, Zhang Rui, Fu Yongshui
Abstract excerpt
Red blood cells (RBCs) of Asian-type DEL phenotype express few RhD proteins and are typed as serologic RhD-negative (D-) phenotype in routine testing. RhD-positive (D+) RBC transfusion for patients with Asian-type DEL has been proposed but has not been generally adopted because of a lack of direct evidence regarding its safety and the underlying mechanism. We performed a single-arm multicenter clinical trial to...
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