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Article

Wolbachia RNase HI contributes to virus blocking in the mosquito Aedes aegypti

19 Dec 2022

Abstract excerpt

The endosymbiotic bacterium Wolbachia pipientis blocks replication of several arboviruses in transinfected Aedes aegypti mosquitoes. However, the mechanism of virus blocking remains poorly understood. Here, we characterized an RNase HI gene from Wolbachia , which is rapidly induced in response to dengue virus (DENV) infection. Knocking down wRNase HI using antisense RNA in Wolbachia -transinfected mosquito cell...

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PMID: 36636344
DOI: 10.1016/j.isci.2022.105836

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