Article
Epilepsy severity mediates association between mutation type and ADHD symptoms in tuberous sclerosis complex.
Epilepsia - 1 Mar 2023
Tye Charlotte, McEwen Fiona S, Liang Holan, Woodhouse Emma, Underwood Lisa, Shephard Elizabeth, Barker Edward D, Sheerin Fintan, Higgins Nicholas, Steenbruggen Juul, Bolton Patrick F
Abstract excerpt
The association between attention-deficit/hyperactivity disorder (ADHD) and tuberous sclerosis complex (TSC) is widely reported, with support for the role of epilepsy, yet the mechanisms underlying the association across development are unclear. The Tuberous Sclerosis 2000 Study is a prospective longitudinal study of TSC. In Phase 1 of the study, baseline measures of epilepsy, cortical tuber load, and mutation...
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