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Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors

11 Jan 2023

Abstract excerpt

Parvovirus B19 (B19V) infects human erythroid progenitor cells (EPCs) and causes several hematological disorders and fetal hydrops. Amino acid (aa) 5–68 of minor capsid protein VP1 (VP1u 5–68aa ) is the minimal receptor binding domain for B19V to enter EPCs. Here, we carried out a genome-wide CRISPR-Cas9 guide RNA screen and identified tyrosine protein kinase receptor UFO (AXL) as a proteinaceous receptor for...

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PMID: 36630517
DOI: 10.1126/sciadv.ade0869

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