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Article

Cardiotoxicity and pharmacogenetics of doxorubicin in black Zimbabwean breast cancer patients.

British journal of clinical pharmacology - 1 Aug 2024

Nyangwara Vincent Aketch, Mazhindu Tinashe, Chikwambi Zedias, Masimirembwa Collen, Campbell Thomas B, Borok Margaret, Ndlovu Ntokozo

Abstract excerpt

AIMS: Doxorubicin-induced cardiotoxicity (DIC) is a significant cause of mortality in cancer care. This study was conducted to establish the frequency of DIC in Zimbabwean breast cancer patients on doxorubicin and to test the DIC predictive power of genetic biomarkers. METHODS: A cohort of 50 Zimbabwean breast cancer patients treated with doxorubicin were followed up for 12 months with serial echocardiography and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36630266
DOI: 10.1111/bcp.15659

Genes

RARG
SLC28A3
UGT1A6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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