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Article

Covalent Rescue of Mutant p53

9 Jan 2023

Abstract excerpt

SUMMARY: p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3).

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Identifiers

PMID: 36620883
DOI: 10.1158/2159-8290.cd-22-1212

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