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Article

PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids.

Cells - 28 Dec 2022

Nanayakkara Merlin, Bellomo Claudia, Furone Francesca, Maglio Mariantonia, Marano Antonella, Lania Giuliana, Porpora Monia, Nicoletti Martina, Auricchio Salvatore, Barone Maria Vittoria

Abstract excerpt

BACKGROUND & AIMS: Celiac disease (CeD) is an immune-mediated enteropathy triggered in genetically susceptible (HLA-DQ2/8) individuals by a group of wheat proteins and related prolamins from cereals. The celiac intestine is characterized by an inversion of the differentiation/proliferation program of the enterocytes, with an increase in the proliferative compartment and crypt hyperplasia, which are the mechanisms...

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Identifiers

PMID: 36611909
DOI: 10.3390/cells12010115
PMCID: PMC9818839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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