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Article

Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex.

Physical chemistry chemical physics : PCCP - 27 Jan 2023

Batool Zahida, Qureshi Urooj, Mushtaq Mamona, Ahmed Sarfaraz, Nur-E-Alam Mohammad, Ul-Haq Zaheer

Abstract excerpt

In silico strategies offer a reliable, fast, and inexpensive, way compared to the clumsy in vitro approaches to boost understanding of the effect of amino acid substitution on the structure and consequently the associated function of proteins. In the present work, we report an atomistic-based, reliable in silico structural and energetic framework of the interactions between the receptor-binding domain of the...

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PMID: 36607223
DOI: 10.1039/d2cp03012h

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