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Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity

30 Dec 2022

Abstract excerpt

IMPORTANCE: Vascular dysfunction and capillary leak are common in critically ill COVID-19 patients, but identification of endothelial pathways involved in COVID-19 pathogenesis has been limited. Angiopoietin-like 4 (ANGPTL4) is a protein secreted in response to hypoxic and nutrient-poor conditions that has a variety of biological effects including vascular injury and capillary leak. OBJECTIVES: To assess the role...

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PMID: 36600780
DOI: 10.1097/cce.0000000000000827

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