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Torque teno mini virus driven childhood acute promyelocytic leukemia: The third case report and sequence analysis

15 Dec 2022

Abstract excerpt

In this manuscript, we report torque teno mini virus (TTMV) as a cause of acute promyelocytic leukemia (APL) lacking PML::RARA in a 3-year-old boy. Astolfi et al. firstly identified partial integration of the TTMV genome into RARA intron 2, which resulted in in-frame TTMV::RARA fusion in two APL-like pediatric cases without PML::RARA in November 2021. This fascinating report identified an unexpected exogenous...

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PMID: 36591487
DOI: 10.3389/fonc.2022.1074913

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