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Article

Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch.

Circulation. Genomic and precision medicine - 1 Feb 2023

Cunningham Jonathan W, Di Achille Paolo, Morrill Valerie N, Weng Lu-Chen, Choi Seung Hoan, Khurshid Shaan, Nauffal Victor, Pirruccello James P, Solomon Scott D, Batra Puneet, Ho Jennifer E, Philippakis Anthony A, Ellinor Patrick T, Lubitz Steven A

Abstract excerpt

BACKGROUND: Absence of a dicrotic notch on finger photoplethysmography is an easily ascertainable and inexpensive trait that has been associated with age and prevalent cardiovascular disease. However, the trait exists along a continuum, and little is known about its genetic underpinnings or prognostic value for incident cardiovascular disease. METHODS: In 169 787 participants in the UK Biobank, we identified...

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Identifiers

PMID: 36580284
DOI: 10.1161/CIRCGEN.121.003676
PMCID: PMC9975074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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