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Article

Design of Crotoxin-Based Peptides with Potentiator Activity Targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

Journal of molecular biology - 1 Feb 2023

Ravatin Marc, Odolczyk Norbert, Servel Nathalie, Guijarro J Iñaki, Tagat Eric, Chevalier Benoit, Baatallah Nesrine, Corringer Pierre-Jean, Lukács Gergely L, Edelman Aleksander, Zielenkiewicz Piotr, Chambard Jean-Marie, Hinzpeter Alexandre, Faure Grazyna

Abstract excerpt

We have previously shown that the CBb subunit of crotoxin, a β-neurotoxin with phospholipase A2 (PLA2) activity, targets the human ΔF508CFTR chloride channel implicated in cystic fibrosis (CF). By direct binding to the nucleotide binding domain 1 (NBD1) of ΔF508CFTR, this neurotoxic PLA2 acts as a potentiator increasing chloride channel current and corrects the trafficking defect of misfolded ΔF508CFTR inside the...

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Identifiers

PMID: 36566799
DOI: 10.1016/j.jmb.2022.167929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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