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Article

Dysregulated Expression of Transposable Elements in TDP-43M337V Human Motor Neurons That Recapitulate Amyotrophic Lateral Sclerosis In Vitro.

International journal of molecular sciences - 19 Dec 2022

Valdebenito-Maturana Braulio, Rojas-Tapia Matias Ignacio, Carrasco Mónica, Tapia Juan Carlos

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a disease that progressively annihilates spinal cord motor neurons, causing severe motor decline and death. The disease is divided into familial and sporadic ALS. Mutations in the TAR DNA binding protein 43 (TDP-43) have been involved in the pathological emergence and progression of ALS, although the molecular mechanisms eliciting the disease are unknown. Transposable...

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Identifiers

PMID: 36555863
DOI: 10.3390/ijms232416222
PMCID: PMC9784876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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