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Cryo-EM structures of infectious bursal disease viruses with different virulences provide insights into their assembly and invasion

13 Dec 2021

Abstract excerpt

Infectious bursal disease virus (IBDV) causes a highly contagious immunosuppressive disease in chickens, resulting in significant economic losses. The very virulent IBDV strain (vvIBDV) causes high mortality and cannot adapt to cell culture. In contrast, attenuated strains of IBDV are nonpathogenic to chickens and can replicate in cell culture. Although the crystal structure of T = 1 subviral particles (SVP) has...

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PMID: 36546126
DOI: 10.1016/j.scib.2021.12.009

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