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Article

Heterophyllin B inhibits the malignant phenotypes of gastric cancer cells via CXCR4.

Human cell - 1 Mar 2023

Wei Yunhai, Yin Lei, Zhang Jinyu, Tang Jianing, Yu Xiaofeng, Wu Zhongxin, Gao Yuhai

Abstract excerpt

Heterophyllin B (HB) is a cyclic lipopeptide that has been shown to have anticancer effects. This study intended to further explore the effects and modulatory mechanism of HB in gastric cancer (GC) cells. The binding relationship between HB and CXCR4 was investigated by network pharmacological analysis, molecular docking, and cellular thermal shift assay (CETSA)-WB assay. Cellular assays revealed that HB could...

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Identifiers

PMID: 36539682
DOI: 10.1007/s13577-022-00824-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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