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Article

Arginase-1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver.

Cancer medicine - 1 Apr 2023

Bonometti Arturo, Borsani Oscar, Rumi Elisa, Ferretti Virginia Valeria, Dioli Claudia, Lucato Elena, Paulli Marco, Boveri Emanuela

Abstract excerpt

INTRODUCTION: Philadelphia-negative myeloproliferative neoplasms (MPN) are clonal myeloid proliferative disorders characterized by sustained systemic inflammation. Despite its renowned importance, the knowledge concerning the inflammatory pathophysiology of these conditions is currently limited to studies on serum cytokines, while cellular immunity has rarely been investigated. METHODS: In the present study, we...

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PMID: 36524315
DOI: 10.1002/cam4.5542
PMCID: PMC10134329

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