Article
Multiple introductions and recombination events underlie the emergence of a hyper-transmissible Cryptosporidium hominis subtype in the USA.
Cell host & microbe - 11 Jan 2023
Huang Wanyi, Guo Yaqiong, Lysen Colleen, Wang Yuanfei, Tang Kevin, Seabolt Matthew H, Yang Fengkun, Cebelinski Elizabeth, Gonzalez-Moreno Olga, Hou Tianyi, Chen Chengyi, Chen Ming, Wan Muchun, Li Na, Hlavsa Michele C, Roellig Dawn M, Feng Yaoyu, Xiao Lihua
Abstract excerpt
The parasite Cryptosporidium hominis is a leading cause of the diarrheal disease cryptosporidiosis, whose incidence in the United States has increased since 2005. Here, we show that the newly emerged and hyper-transmissible subtype IfA12G1R5 is now dominant in the United States. In a comparative analysis of 127 newly sequenced and 95 published C. hominis genomes, IfA12G1R5 isolates from the United States place...
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