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The SARS-CoV-2 spike protein binds and modulates estrogen receptors

30 Nov 2022

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme 2 as its primary infection mechanism. Interactions between S and endogenous proteins occur after infection but are not well understood. We profiled binding of S against >9000 human proteins and found an interaction between S and human estrogen receptor α (ERα). Using bioinformatics,...

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PMID: 36449624
DOI: 10.1126/sciadv.add4150

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