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Article

Association of adenosine triphosphate-related genes to major depression and suicidal behavior: Cognition as a potential mediator.

Journal of affective disorders - 15 Feb 2023

Zheng Shuqiong, Guo Jia, Xin Qianqian, Galfalvy Hanga, Ye Youran, Yan Na, Qian Rongrong, Mann J John, Li Enze, Xue Xiang, Yin Honglei

Abstract excerpt

BACKGROUND: Soluble epoxide hydrolase (sEH, encoded by EPHX2) and P2X2 (a subtype of ATP receptors) may mediate the antidepressant-like effects of ATP. We sought to determine whether polymorphisms and mRNA expression of EPHX2 and P2X2 are associated with depression and suicidal behavior and how cognition may mediate such associations. METHOD: We examined 83 single nucleotide polymorphisms (SNPs) of EPHX2 and...

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PMID: 36442653
DOI: 10.1016/j.jad.2022.11.042

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