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Article

Resident intruder paradigm-induced PMDD rat model of premenstrual irritability: behavioral phenotypes, drug intervention, and biomarkers.

Aging - 27 Nov 2022

Gao Mingzhou, Zhang Hao, Gao Zhan, Sun Ya, Xu Guanghao, Wei Fengqin, Wang Jieqiong, Gao Dongmei

Abstract excerpt

BACKGROUND: Premenstrual dysphoric disorder (PMDD) is high in women of childbearing age with obvious premenstrual irritability. However, reliable animal models are still lacking. MATERIALS AND METHODS: PMDD rat model of premenstrual irritability was induced by the resident-intruder paradigm (RIP). Behavioral characteristics were determined by the aggressive behavior test, elevated plus maze, open-field test, and...

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PMID: 36441533
DOI: 10.18632/aging.204402
PMCID: PMC9740374

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