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Article

Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia

27 Nov 2022

Abstract excerpt

Abstract Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid leukemia (AML). Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid differentiation. To explore the therapeutic potential of GPR132 signaling, we screened and validated a...

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PMID: 36437247
DOI: 10.1038/s41419-022-05434-z

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