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Article

Variable number tandem repeats (VNTRs) as modifiers of breast cancer risk in carriers of BRCA1 185delAG.

European journal of human genetics : EJHG - 1 Feb 2023

Ding Yuan Chun, Adamson Aaron W, Bakhtiari Mehrdad, Patrick Carmina, Park Jonghun, Laitman Yael, Weitzel Jeffrey N, Bafna Vineet, Friedman Eitan, Neuhausen Susan L

Abstract excerpt

Despite substantial efforts in identifying both rare and common variants affecting disease risk, in the majority of diseases, a large proportion of unexplained genetic risk remains. We propose that variable number tandem repeats (VNTRs) may explain a proportion of the missing genetic risk. Herein, in a pilot study with a retrospective cohort design, we tested whether VNTRs are causal modifiers of breast cancer...

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Identifiers

PMID: 36434258
DOI: 10.1038/s41431-022-01238-z
PMCID: PMC9905572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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