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Article

Effects of TIMP-2 Polymorphisms on Retinopathy of Prematurity Risk, Severity, Recurrence, and Treatment Response.

International journal of molecular sciences - 17 Nov 2022

Wu Pei-Liang, Ling Xiao Chun, Kang Eugene Yu-Chuan, Chen Kuan-Jen, Wang Nan-Kai, Liu Laura, Chen Yen-Po, Hwang Yih-Shiou, Lai Chi-Chun, Yang Shun-Fa, Wu Wei-Chi

Abstract excerpt

Tissue inhibitors of metalloproteinases (TIMPs) play a crucial role in endogenous angiogenesis besides the regulation of matrix metalloproteinase (MMP) activity. Associations between TIMP-2 gene polymorphisms and the risk of retinopathy of prematurity (ROP) were examined. Premature infants born between 2009 and 2018 were included. Five single-nucleotide polymorphisms (SNPs) of TIMP-2 were analyzed with real-time...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36430677
DOI: 10.3390/ijms232214199
PMCID: PMC9694036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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