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Mechanisms of Corticosteroid Resistance in Type 17 Asthma

1 Nov 2022

Abstract excerpt

IL-17A plays an important role in the pathogenesis of asthma, particularly the neutrophilic corticosteroid (CS)-resistant subtype of asthma. Clinical studies suggest that a subset of asthma patients, i.e., Th17/IL-17A-mediated (type 17) CS-resistant neutrophilic asthma, may improve with Th17/IL-17A pathway blockade. However, little is known about the mechanisms underlying type 17 asthma and CS response. In this...

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PMID: 36426949
DOI: 10.4049/jimmunol.2200288

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