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Article

Topology and redescriptions detect multiple alternative biological pathways from clinical phenotypes.

Experimental biology and medicine (Maywood, N.J.) - 1 Nov 2022

Karisani Negin, Platt Daniel E, Basu Saugata, Parida Laxmi

Abstract excerpt

Biological pathways play a crucial role in the properties of diseases and are important in drug discovery. Identifying the logical relationships among distinctive phenotypic clusters could reveal possible connections to the underlying pathways. However, this process is challenging since clinical phenotypes are often available through unstructured electronic health records. Moreover, in the absence of a...

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PMID: 36398440
DOI: 10.1177/15353702221126671
PMCID: PMC9679317

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