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Article

The need for evolutionary theory in cancer research.

European journal of epidemiology - 1 Dec 2023

Boddy Amy M

Abstract excerpt

Sir Richard Peto is well known for proposing puzzling paradoxes in cancer biology-some more well-known than others. In a 1984 piece, Peto proposed that after decades of molecular biology in cancer research, we are still ignorant of the biology underpinning cancer. Cancer is a product of somatic mutations. How do these mutations arise and what are the mechanisms? As an epidemiologist, Peto asked if we really need...

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PMID: 36385398
DOI: 10.1007/s10654-022-00936-8
PMCID: PMC10757905

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