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Article

Investigation of clinical characteristics and genome associations in the 'UK Lipoedema' cohort.

PloS one - 1 Jan 2022

Grigoriadis Dionysios, Sackey Ege, Riches Katie, van Zanten Malou, Brice Glen, England Ruth, Mills Mike, Dobbins Sara E, Lee Li Ling, Jeffery Steve, Dong Liang, Savage David B, Mortimer Peter S, Keeley Vaughan, Pittman Alan, Gordon Kristiana, Ostergaard Pia

Abstract excerpt

Lipoedema is a chronic adipose tissue disorder mainly affecting women, causing excess subcutaneous fat deposition on the lower limbs with pain and tenderness. There is often a family history of lipoedema, suggesting a genetic origin, but the contribution of genetics is currently unclear. A tightly phenotyped cohort of 200 lipoedema patients was recruited from two UK specialist clinics. Objective clinical...

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PMID: 36227936
DOI: 10.1371/journal.pone.0274867
PMCID: PMC9560129

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