Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The severity of SARS‐CoV‐2 infection in K18‐hACE2 mice is attenuated by a novel steroid‐derivative in a gender‐specific manner

1 Jun 2023

Abstract excerpt

Abstract Background and Purpose COVID‐19 infections caused by SARS‐CoV‐2 disseminated through human‐to‐human transmission can evoke severe inflammation. Treatments to reduce the SARS‐CoV‐2‐associated inflammation are needed and are the focus of much research. In this study, we investigated the effect of N‐ethyl‐N′‐[(3β,5α)‐17‐oxoandrostan‐3‐yl] urea (NEOU), a novel 17α‐ketosteroid derivative, on the severity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Pharmacological Receptor Mechanisms and Effects
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37259182
DOI: 10.1111/bph.16155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The severity of SARS‐CoV‐2 infection in K18‐hACE2 mice is attenuated by a novel steroid‐derivative in a gender‐specific mannerPMID 37259182Read ↗

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory diseaseSemantic proximity Read ↗

Delayed viral clearance and altered inflammatory responses resulted in increased severity of SARS-CoV-2 infection in aged miceSemantic proximity Read ↗

Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine modelSemantic proximity Read ↗

SeXX and COVID-19: Tussle between the TwoSemantic proximity Read ↗

Differential outcomes of infection by wild-type SARS-CoV-2 and the B.1.617.2 and B.1.1.529 variants of concern in K18-hACE2 transgenic miceSemantic proximity Read ↗

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19Semantic proximity Read ↗

Differential Immunometabolism and Tissue Responses to Delta and Omicron SARS-CoV-2 Variants in Golden Syrian Hamster ModelsSemantic proximity Read ↗

Differential Immunometabolism and Tissue Responses to Delta and Omicron SARS-CoV-2 Variants in Golden Syrian Hamster ModelsSemantic proximity Read ↗

Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infectionSemantic proximity Read ↗

Evaluation of K18- <i>hACE2</i> mice as a model of SARS-CoV-2 infectionSemantic proximity Read ↗

What's Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses.Semantic proximity Read ↗

Delta (B1.617.2) variant of SARS-CoV-2 induces severe neurotropic patterns in K18-hACE2 miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.