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A spectrum of BRCA1 and BRCA2 germline deleterious variants in ovarian cancer in Russia.

Breast cancer research and treatment - 1 Jan 2023

Kechin Andrey, Boyarskikh Ulyana, Barinov Alexey, Tanas Alexander, Kazakova Svetlana, Zhevlova Anastasia, Khrapov Evgeniy, Subbotin Sergey, Mishukova Olga, Kekeeva Tatiana, Demidova Irina, Filipenko Maxim

Abstract excerpt

PURPOSE: Pathogenic variants (PVs) in BRCA1 and BRCA2 genes are essential biomarkers of an increased breast and ovarian cancer risk and tumor sensitivity to poly ADP ribose polymerase inhibitors. In Russia, eight PVs were thought to be the most common, among which BRCA1 c.5266dup is the most frequently identified one. METHODS: We show the distribution of BRCA1/2 PVs identified with quantitative PCR and targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36367610
DOI: 10.1007/s10549-022-06782-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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