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Article

The Significance of MGMT Promoter Methylation Status in Diffuse Glioma

27 Oct 2022

Abstract excerpt

A single-institution observational study with 43 newly diagnosed diffuse gliomas defined the isocitrate dehydrogenase 1 and 2 (IDH1/2) gene mutation status and evaluated the prognostic relevance of the methylation status of the epigenetic marker O6-methylguanine-DNA methyltransferase (MGMT). Younger patients (<50 years) with surgically resected glioma and temozolomide (TMZ) adjuvant chemotherapy were associated...

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PMID: 36361838
DOI: 10.3390/ijms232113034

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