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Article

Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.

The Journal of clinical investigation - 3 Jan 2023

Bhattacharya Shreya, Basu Sayon, Sheng Emily, Murphy Christina, Wei Jenny, Kersh Anna E, Nelson Caroline A, Bryer Joshua S, Ashchyan Hovik A, Steele Katherine, Forrestel Amy, Seykora John T, Micheletti Robert G, James William D, Rosenbach Misha, Leung Thomas H

Abstract excerpt

BackgroundAcute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and a rash with a neutrophilic infiltrate. The disease pathophysiology remains elusive, and current dogma suggests that Sweet syndrome is a process of reactivity to an unknown antigen. Corticosteroids and steroid-sparing agents remain frontline therapies,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36355435
DOI: 10.1172/JCI162137
PMCID: PMC9797331

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