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Anlotinib plus chemotherapy for T790M-negative EGFR-mutant non-sqNSCLC resistant to TKIs: A multicenter phase 1b/2 trial.

Thoracic cancer - 1 Dec 2022

Li Juan, Tian Yuke, Zheng Min, Ge Jun, Zhang Jiliang, Kong Dejun, Chen Mei, Yu Ping

Abstract excerpt

BACKGROUND: This multicenter phase 1b/2 trial aimed to explore the maximum tolerated dose (MTD), activity, and safety of anlotinib plus chemotherapy in patients with T790M-negative epidermal growth factor receptor (EGFR)-mutant advanced nonsquamous non-small cell lung cancer (NSCLC) after resistance to first- or second-generation EGFR tyrosine kinase inhibitors (TKIs). METHODS: In the phase 1b stage, patients...

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Identifiers

PMID: 36346139
DOI: 10.1111/1759-7714.14713
PMCID: PMC9750808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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