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Article

Gene-centric multi-omics integration with convolutional encoders for cancer drug response prediction

17 Oct 2022

Abstract excerpt

MOTIVATION: Tumor heterogeneity, including genetic and transcriptomic characteristics, can reduce the efficacy of anticancer pharmacological therapy, resulting in clinical variability in patient response to therapeutic medications. Multi-omics integration can allow in silico models to provide an additional perspective on a biological system. METHODS: In this study, we propose a gene-centric multi-channel (GCMC)...

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PMID: 36327883
DOI: 10.1016/j.compbiomed.2022.106192

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