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Article

Generation of viperin-knockout zebrafish by CRISPR/Cas9-mediated genome engineering and the effect of this mutation under VHSV infection.

Fish & shellfish immunology - 1 Dec 2022

Shanaka K A S N, Jung Sumi, Madushani K P, Wijerathna H M S M, Neranjan Tharuka M D, Kim Myoung-Jin, Lee Jehee

Abstract excerpt

Viperin is an important virus-induced protein in animals that negatively participates in RNA viral replication and transcription. The reactive machinery of viperin suggests that it produces a regulatory molecule ddhCTP, which may affect immune regulation. In this study, we investigated the expression pattern of viperin in larval and adult stages of zebrafish by whole-mount in situ hybridization and reverse...

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PMID: 36309322
DOI: 10.1016/j.fsi.2022.10.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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