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Article

Mitochondrial tRNAGln 4394C>T Mutation May Contribute to the Clinical Expression of 1555A>G-Induced Deafness

Genes - 5 Oct 2022

Ding Yu, Teng Yaoshu, Guo Qinxian, Leng Jianhang

Abstract excerpt

The mitochondrial 1555A>G mutation plays a critical role in aminoglycoside-induced and non-syndromic hearing loss (AINSHL). Previous studies have suggested that mitochondrial secondary variants may modulate the clinical expression of m.1555A>G-induced deafness, but the molecular mechanism has remained largely undetermined. In this study, we investigated the contribution of a deafness-associated tRNAGln 4394C>T...

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Identifiers

PMID: 36292680
DOI: 10.3390/genes13101794
PMCID: PMC9602358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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