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Article

SF3B1 mutated MDS: Blast count, genetic co-abnormalities and their impact on classification and prognosis.

Leukemia - 1 Dec 2022

Huber Sandra, Haferlach Torsten, Meggendorfer Manja, Hutter Stephan, Hoermann Gregor, Baer Constance, Kern Wolfgang, Haferlach Claudia

Abstract excerpt

Recently, MDS with mutated SF3B1 and blast count <5% was proposed as distinct entity with favorable prognosis by the international working group for the prognosis of MDS (IWG-PM), the 5th edition of the WHO classification and the International Consensus Classification. To further characterize this entity with respect to the genomic landscape, AML transformation rate and clinical outcome, we analyzed 734 MDS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36261576
DOI: 10.1038/s41375-022-01728-5
PMCID: PMC9712089

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