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Blood donor biobank and HLA imputation as a resource for HLA homozygous cells for therapeutic and research use

9 Oct 2022

Abstract excerpt

BACKGROUND: Allogeneic therapeutic cells may be rejected if they express HLA alleles not found in the recipient. As finding cell donors with a full HLA match to a recipient requires vast donor pools, the use of HLA homozygous cells has been suggested as an alternative. HLA homozygous cells should be well tolerated by those who carry at least one copy of donor HLA alleles. HLA-A-B homozygotes could be valuable for...

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PMID: 36210465
DOI: 10.1186/s13287-022-03182-7

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