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Unbiased screen for pathogens in human paraffin-embedded tissue samples by whole genome sequencing and metagenomics

20 Sept 2022

Abstract excerpt

Identification of bacterial pathogens in formalin fixed, paraffin embedded (FFPE) tissue samples is limited to targeted and resource-intensive methods such as sequential PCR analyses. To enable unbiased screening for pathogens in FFPE tissue samples, we established a whole genome sequencing (WGS) method that combines shotgun sequencing and metagenomics for taxonomic identification of bacterial pathogens after...

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PMID: 36204644
DOI: 10.3389/fcimb.2022.968135

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