Article
A whole genome sequencing approach to anterior cruciate ligament rupture-a twin study in two unrelated families.
PloS one - 1 Jan 2022
Feldmann Daneil, Bope Christian D, Patricios Jon, Chimusa Emile R, Collins Malcolm, September Alison V
Abstract excerpt
Predisposition to anterior cruciate ligament (ACL) rupture is multi-factorial, with variation in the genome considered a key intrinsic risk factor. Most implicated loci have been identified from candidate gene-based approach using case-control association settings. Here, we leverage a hypothesis-free whole genome sequencing in two two unrelated families (Family A and B) each with twins with a history of recurrent...
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