Article
Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model.
Physiological reports - 1 Oct 2022
Takahashi Tsukasa, Takahashi Yuki, Fee Erin L, Usuda Haruo, Furfaro Lucy, Newnham John P, Jobe Alan H, Kemp Matthew W
Abstract excerpt
Treatment with antenatal steroids (ANS) is standard practice for reducing the risk of respiratory distress in the preterm infant. Despite clear overall benefits when appropriately administered, many fetuses fail to derive benefit from ANS therapies. In standardized experiments using a pregnant sheep model, we have demonstrated that around 40% of ANS-exposed lambs did not have functional lung maturation...
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