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Article

Endothelial Cell-Derived Let-7c-Induced TLR7 Activation on Smooth Muscle Cell Mediate Vascular Wall Remodeling in Moyamoya Disease.

Translational stroke research - 1 Aug 2023

Ma Xiaopeng, Huang Yimin, He Xuejun, Zhang Xincheng, Liu Yanchao, Yang Yiping, Yue Pengjie, Liu Yuan, Gan Chao, Shu Kai, Lei Ting, Wang Sheng, Zhang Huaqiu

Abstract excerpt

Moyamoya disease (MMD) is characterized by frequent migration and phenotypic transformation of vascular smooth muscle cells (VSMCs) in the intima layer of blood vessels. However, the underlying mechanism is unclear. Toll-like receptor (TLR) 7 is abundantly expressed in smooth muscle cells (SMCs) in multiple vascular diseases, which might be linked to the disease-associated vascular remodeling. In the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36181627
DOI: 10.1007/s12975-022-01088-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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